| Carboxymethylcellulose Sodium | Thickener/Stabilizer | ⚠️ Yes — CMC | A cellulose derivative used as a thickener. Rare CMC reactions reported in medical literature. |
| Cetyl Alcohol | Emulsifier/Thickener | ⚠️ Yes — Cetyl Alcohol | A fatty alcohol used in topical formulations. Can cause contact dermatitis. |
| Egg Phospholipids | — | ⚠️ Yes — Egg | — |
| Medium-chain Triglycerides | Solvent/Vehicle | ⚠️ Yes — Coconut | Fatty acid esters derived from coconut or palm kernel oil. Used as a solvent and vehicle in oral and topical formulations. May be relevant for individuals with coconut sensitivity. |
| PEG-100 Monostearate | Emulsifier | ⚠️ Yes — PEG | A PEG-based emulsifier used to stabilize oil-in-water emulsions in creams and lotions. Contains a polyethylene glycol component. |
| Peg/ppg-18/18 Dimethicone? | Emulsifier/Skin Conditioner | ?Uncertain — PEG | A silicone-based emulsifier combining PEG and polypropylene glycol with dimethicone. Used in topical formulations for smooth application. |
| Propylene Glycol | Solvent/Humectant | ⚠️ Yes — Propylene Glycol | An organic compound used as a solvent and humectant. Can cause contact dermatitis in sensitive individuals. |
| Sesame Oil? | Vehicle/Solvent | ?Uncertain — Sesame | A seed oil used as a vehicle in some injectable medications and topical formulations. Sesame is a recognized major food allergen (FASTER Act, 2023) — patients with sesame allergy should verify all formulations. |
| Sodium Benzoate | Preservative | ⚠️ Yes — Sodium Benzoate | A food preservative. Can cause urticaria and exacerbate asthma in sensitive individuals. |
| .alpha.-tocopherol? | Antioxidant | No | The most biologically active form of vitamin E. Used to protect formulations from oxidative degradation. |
| .alpha.-tocopherol Acetate | Antioxidant | No | Vitamin E acetate. Used as an antioxidant to protect active ingredients from degradation during storage. |
| 2-aminoethanol? | — | No | — |
| Aluminum Oxide | Abrasive/Adsorbent | No | Alumina. Used as an adsorbent, abrasive, and processing aid in pharmaceutical manufacturing. |
| Carbomer Homopolymer | Thickener/Gelling Agent | No | A synthetic acrylic acid polymer used to create gels and thicken topical formulations. |
| Carbon Dioxide | Propellant/Preservative | No | Used as a propellant in aerosol products and to displace oxygen in packaging to preserve product stability. |
| Citric Acid Monohydrate | pH Adjuster/Buffer | No | Citric acid in its hydrated form. Used to adjust acidity and as a buffering agent. Derived from citrus fruits or fermentation. |
| Cyclomethicone | — | No | — |
| Cyclomethicone 5 | Emollient/Carrier | No | A volatile silicone that evaporates quickly, leaving a smooth feel. Used as a carrier and emollient in topical products. |
| Dimethicone 20 | Skin Protectant | No | A silicone-based polymer used as a skin protectant, emollient, and anti-foaming agent in topical formulations. |
| Edetate Trisodium | — | No | — |
| Ethylhexyl Hydroxystearate? | Emollient | No | A synthetic ester used as an emollient and skin-conditioning agent in topical formulations. |
| Ferric Oxide Red | Colorant | No | Red iron oxide pigment used in tablet coatings and capsule shells. A mineral-based colorant, distinct from FD&C synthetic dyes. |
| Ferric Oxide Yellow | Colorant | No | Yellow iron oxide pigment used in tablet coatings and capsule shells. A mineral-based colorant. |
| Ferrosoferric Oxide | Colorant | No | Black iron oxide used as a pigment in tablet coatings and capsule shells. Derived from iron, not from food allergen sources. |
| Glutamic Acid Hydrochloride? | — | No | — |
| Glycerin | Humectant/Solvent | No | A sugar alcohol that attracts moisture. Used as a humectant, solvent, and sweetener in many oral and topical medications. Generally well tolerated. |
| Glyceryl Monostearate | Emulsifier | No | An emulsifier that helps oil and water mix in creams and ointments. Derived from glycerin and stearic acid. |
| Hamamelis Virginiana Top Water | Skin Conditioner | No | Witch hazel distillate, a plant-derived astringent used in topical formulations to soothe and tone the skin. |
| Leucine | — | No | — |
| Lysine Acetate | — | No | — |
| Magnesium Aluminum Silicate | Suspending Agent/Thickener | No | A natural clay mineral used to thicken and stabilize pharmaceutical suspensions and topical formulations. |
| Menthol? | Flavoring/Counterirritant | No | A compound derived from peppermint oil that produces a cooling sensation. Used as a flavoring agent and topical counterirritant. |
| N,n-dimethylacetamide? | Solvent | No | An organic solvent used in transdermal and topical formulations to dissolve active ingredients. |
| Olive Oil | Emollient/Vehicle | No | A plant-derived oil used as an emollient and vehicle in topical formulations. |
| Phenoxyethanol | Preservative | No | A synthetic preservative used to prevent microbial growth in topical and some oral formulations. Can cause skin irritation in sensitive individuals. |
| Potassium Sorbate | Preservative | No | A potassium salt of sorbic acid used to inhibit mold and yeast growth in pharmaceutical formulations. |
| Proline | — | No | — |
| Serine | — | No | — |
| Squalane | Emollient | No | A saturated hydrocarbon used as an emollient and moisturizer. Originally from shark liver oil, now commonly plant-derived (olive or sugarcane). |
| Xanthan Gum | Thickener/Stabilizer | No | A polysaccharide produced by bacterial fermentation, used to thicken and stabilize liquid and semi-solid formulations. Derived from corn sugar fermentation — may be relevant for corn-sensitive individuals. |