ARTICAINE (Articaine Hydrochloride and Epinephrine) 40 mg / 0.01 mg

INJECTION, SOLUTIONSUBMUCOSALPatterson DentalNDC: 50227-1040Updated: Mar 2026

Active Ingredients

⚠️ 1 ingredient flagged as common allergen

Sodium Metabisulfite

⚠️ Yes — Sulfite

Antioxidant/Preservative

Hamamelis Virginiana Top Water

Skin Conditioner

Sodium Chloride

Tonicity Agent

Sodium Hydroxide

pH Adjuster

Ingredient	Purpose	Common Allergen?	Description
Sodium Metabisulfite	Antioxidant/Preservative	⚠️ Yes — Sulfite	A sulfite compound used as an antioxidant and preservative. Can trigger severe reactions (bronchospasm, anaphylaxis) in sulfite-sensitive individuals, particularly asthmatics.
Hamamelis Virginiana Top Water	Skin Conditioner	No	Witch hazel distillate, a plant-derived astringent used in topical formulations to soothe and tone the skin.
Sodium Chloride	Tonicity Agent	No	Common table salt. Used to adjust the osmotic pressure of injectable and ophthalmic solutions to match body fluids.
Sodium Hydroxide	pH Adjuster	No	A strong alkali used to adjust the pH of pharmaceutical solutions. Present only in trace amounts in the final product.

This medication contains ingredients flagged in the following groups. Patients with these sensitivities should consult their prescriber.