Acetaminophen and Ibuprofen (ACETAMINOPHEN AND IBUPROFEN)

ORALAMERISOURCE BERGENNDC: 46122-742-68Updated: Mar 2026

Nonsteroidal Anti-inflammatory Drug

Active Ingredients

Active ingredients (in each caplet) Acetaminophen

USP 250 mg Ibuprofen

USP 125 mg (NSAID*) *nonsteroidal anti-inflammatory drug

Inactive Ingredients (Fillers)

⚠️ 5 ingredients flagged as common allergens

Crospovidone

⚠️ Yes — Povidone

Disintegrant

Polyethylene Glycol

⚠️ Yes — PEG

Coating/Plasticizer

Povidone K17

⚠️ Yes — Povidone

Pregelatinized Starch

⚠️ Yes — Corn

Binder/Disintegrant

Sodium Lauryl Sulfate

⚠️ Yes — Surfactant

Wetting Agent

Croscarmellose Sodium

Disintegrant

Dextrose Monohydrate?

Ferric Oxide Brown?

Ferric Oxide Red

Colorant

Glyceryl Distearate?

Hypromellose

Coating

Magnesium Stearate

Lubricant

Microcrystalline Cellulose

Filler/Binder

Silicon Dioxide?

Glidant

Titanium Dioxide

Colorant/Opacifier

Ingredient	Purpose	Common Allergen?	Description
Crospovidone	Disintegrant	⚠️ Yes — Povidone	A cross-linked form of povidone used as a superdisintegrant. Same polymer allergy concern as povidone.
Polyethylene Glycol	Coating/Plasticizer	⚠️ Yes — PEG	A polymer used in coatings and as a plasticizer. Rare but documented allergic reactions, including anaphylaxis in sensitive individuals.
Povidone K17	—	⚠️ Yes — Povidone	—
Pregelatinized Starch	Binder/Disintegrant	⚠️ Yes — Corn	A modified starch (often corn-derived) that may affect individuals with corn sensitivity.
Sodium Lauryl Sulfate	Wetting Agent	⚠️ Yes — Surfactant	A surfactant used to improve drug dissolution. Can cause skin irritation in some individuals.
Croscarmellose Sodium	Disintegrant	No	A chemically modified cellulose derivative that helps tablets dissolve quickly.
Dextrose Monohydrate?	—	No	—
Ferric Oxide Brown?	—	No	—
Ferric Oxide Red	Colorant	No	Red iron oxide pigment used in tablet coatings and capsule shells. A mineral-based colorant, distinct from FD&C synthetic dyes.
Glyceryl Distearate?	—	No	—
Hypromellose	Coating	No	A semisynthetic polymer used for tablet coating. Derived from cellulose.
Magnesium Stearate	Lubricant	No	A lubricant that prevents ingredients from sticking to manufacturing equipment.
Microcrystalline Cellulose	Filler/Binder	No	Refined wood pulp used as a filler and binder. Generally inert and well-tolerated.
Silicon Dioxide?	Glidant	No	A mineral (silica) used to improve powder flow during tablet manufacturing. Also called colloidal silicon dioxide.
Titanium Dioxide	Colorant/Opacifier	No	A white pigment used for coating opacity. Under regulatory review in some countries.