Topotecan hydrochloride (Topotecan hydrochloride) 4 mg

INJECTION, POWDER, LYOPHILIZED, FOR SOLUTIONINTRAVENOUSActavis Pharma, Inc.NDC: 45963-615Updated: Mar 2026

Active Ingredient

⚠️ 1 ingredient flagged as common allergen

Mannitol

⚠️ Yes — Mannitol

Filler/Sweetener

Hydrochloric Acid

pH Adjuster

Sodium Hydroxide

pH Adjuster

Tartaric Acid

pH Adjuster/Effervescent

Ingredient	Purpose	Common Allergen?	Description
Mannitol	Filler/Sweetener	⚠️ Yes — Mannitol	A sugar alcohol used as a sweetener and bulking agent. Can cause osmotic diarrhea in sensitive individuals.
Hydrochloric Acid	pH Adjuster	No	A strong acid used in small amounts to adjust the pH of pharmaceutical solutions. Neutralized in the final product.
Sodium Hydroxide	pH Adjuster	No	A strong alkali used to adjust the pH of pharmaceutical solutions. Present only in trace amounts in the final product.
Tartaric Acid	pH Adjuster/Effervescent	No	A naturally occurring acid used as a pH adjuster and in effervescent formulations.

This medication contains ingredients flagged in the following groups. Patients with these sensitivities should consult their prescriber.