diphenhydramine hydrochloride 12.5 mg

LIQUIDORALRebel Distributors CorpNDC: 21695-689Updated: Mar 2026

Active Ingredient

diphenhydramine hydrochloride — 12.5 mg

Inactive Ingredients (Fillers)

⚠️ 5 ingredients flagged as common allergens

FD&C Red No. 40

⚠️ Yes — Dye

Colorant

Methylparaben

⚠️ Yes — Parabens

Preservative

Propylene Glycol

⚠️ Yes — Propylene Glycol

Solvent/Humectant

Propylparaben

⚠️ Yes — Parabens

Preservative

Saccharin Sodium

⚠️ Yes — Saccharin

Sweetener

Anhydrous Citric Acid

pH Adjuster/Buffer

D&C Red No. 33

Colorant

Disodium Citrate Sesquihydrate

Buffer

Hamamelis Virginiana Top Water

Skin Conditioner

Sorbitol

Sweetener/Humectant

Ingredient	Purpose	Common Allergen?	Description
FD&C Red No. 40	Colorant	⚠️ Yes — Dye	A widely used artificial red dye. Among the most common dye allergens.
Methylparaben	Preservative	⚠️ Yes — Parabens	A preservative used to prevent microbial growth. Can cause allergic contact dermatitis in sensitive individuals.
Propylene Glycol	Solvent/Humectant	⚠️ Yes — Propylene Glycol	An organic compound used as a solvent and humectant. Can cause contact dermatitis in sensitive individuals.
Propylparaben	Preservative	⚠️ Yes — Parabens	A paraben preservative used to prevent microbial growth. Can cause contact dermatitis in paraben-sensitive individuals.
Saccharin Sodium	Sweetener	⚠️ Yes — Saccharin	An artificial sweetener. Rare sensitivities reported, including skin reactions.
Anhydrous Citric Acid	pH Adjuster/Buffer	No	Water-free citric acid used to adjust pH and enhance drug stability. Typically derived from fermentation of corn sugar.
D&C Red No. 33	Colorant	No	A synthetic red dye used in topical formulations and some oral medications. May cause reactions in individuals with dye sensitivities.
Disodium Citrate Sesquihydrate	Buffer	No	A sodium salt of citric acid used as a buffering agent to maintain pH stability in pharmaceutical solutions.
Hamamelis Virginiana Top Water	Skin Conditioner	No	Witch hazel distillate, a plant-derived astringent used in topical formulations to soothe and tone the skin.
Sorbitol	Sweetener/Humectant	No	A sugar alcohol used as a sweetener and humectant. Can cause gastrointestinal symptoms (bloating, diarrhea) in sensitive individuals or at high doses. Relevant for those following a low-FODMAP diet.