DIPHENHYDRAMINE HYDROCHLORIDE 25 mg

Generic for DIPHENHYDRAMINE HYDROCHLORIDE

CAPSULE, LIQUID FILLEDORALRITE AID CORPORATIONNDC: 11822-1565Updated: Mar 2026

Active Ingredient

DIPHENHYDRAMINE HYDROCHLORIDE — 25 mg

Inactive Ingredients (Fillers)

⚠️ 4 ingredients flagged as common allergens

FD&C Blue No. 1

⚠️ Yes — Dye

Colorant

FD&C Red No. 40

⚠️ Yes — Dye

Colorant

Gelatin

⚠️ Yes — Animal

Capsule Shell

Propylene Glycol

⚠️ Yes — Propylene Glycol

Solvent/Humectant

Glycerin

Humectant/Solvent

Hamamelis Virginiana Top Water

Skin Conditioner

Polyethylene Glycol 400

Solvent/Plasticizer

Sorbitol

Sweetener/Humectant

Titanium Dioxide

Colorant/Opacifier

Ingredient	Purpose	Common Allergen?	Description
FD&C Blue No. 1	Colorant	⚠️ Yes — Dye	A synthetic blue dye. Less commonly allergenic than other dyes but reactions are documented.
FD&C Red No. 40	Colorant	⚠️ Yes — Dye	A widely used artificial red dye. Among the most common dye allergens.
Gelatin	Capsule Shell	⚠️ Yes — Animal	Derived from animal collagen. Used in capsule shells. Not suitable for vegetarians/vegans or those with specific animal protein sensitivities.
Propylene Glycol	Solvent/Humectant	⚠️ Yes — Propylene Glycol	An organic compound used as a solvent and humectant. Can cause contact dermatitis in sensitive individuals.
Glycerin	Humectant/Solvent	No	A sugar alcohol that attracts moisture. Used as a humectant, solvent, and sweetener in many oral and topical medications. Generally well tolerated.
Hamamelis Virginiana Top Water	Skin Conditioner	No	Witch hazel distillate, a plant-derived astringent used in topical formulations to soothe and tone the skin.
Polyethylene Glycol 400	Solvent/Plasticizer	No	A low-molecular-weight PEG used as a solvent and plasticizer in oral and topical formulations. Rare but documented allergic reactions to PEG compounds.
Sorbitol	Sweetener/Humectant	No	A sugar alcohol used as a sweetener and humectant. Can cause gastrointestinal symptoms (bloating, diarrhea) in sensitive individuals or at high doses. Relevant for those following a low-FODMAP diet.
Titanium Dioxide	Colorant/Opacifier	No	A white pigment used for coating opacity. Under regulatory review in some countries.

Exclusion Groups

This medication contains ingredients flagged in the following groups. Patients with these sensitivities should consult their prescriber.

🌾Gluten 🔴Alpha-Gal Syndrome 🎨Dyes & Colorants 🍬Polyols (GI)🌱Not Vegan ☪️Halal Concern ✡️Kosher Concern 🥦Not Vegetarian

Dietary & Safety Information

Alpha-Gal Syndrome Risk

2 ingredients may contain mammalian-derived components:

Gelatin(Yes — Mammalian-derived – alpha-gal risk (verify processing/source).)
Glycerin(Possible — Glycerin can be plant- or animal-derived (verify source).)

AllergenMaps

Ingredient

Purpose

Common Allergen?

FD&C Blue No. 1

Colorant

⚠️ Yes — Dye

FD&C Red No. 40

Colorant

⚠️ Yes — Dye

Gelatin

Capsule Shell

⚠️ Yes — Animal

Propylene Glycol

Solvent/Humectant

⚠️ Yes — Propylene Glycol

Glycerin

Humectant/Solvent

Hamamelis Virginiana Top Water

Skin Conditioner

Polyethylene Glycol 400

Solvent/Plasticizer

Sorbitol

Sweetener/Humectant

Titanium Dioxide

Colorant/Opacifier