CALQUENCE (acalabrutinib) 100 mg

TABLET, FILM COATEDORALAstraZeneca Pharmaceuticals LPNDC: 0310-4513Updated: Mar 2026

Active Ingredient

ACALABRUTINIB — 100 mg

Inactive Ingredients (Fillers)

⚠️ 4 ingredients flagged as common allergens

Copovidone K25-31

⚠️ Yes — Povidone

Binder/Film Former

Mannitol

⚠️ Yes — Mannitol

Filler/Sweetener

Medium-chain Triglycerides

⚠️ Yes — Coconut

Solvent/Vehicle

Polyethylene Glycol 3350

⚠️ Yes — PEG

Coating/Osmotic Agent

Ferric Oxide Red

Colorant

Ferric Oxide Yellow

Colorant

Hamamelis Virginiana Top Water

Skin Conditioner

Hypromellose

Coating

Low-substituted Hydroxypropyl Cellulose

Disintegrant/Binder

Microcrystalline Cellulose

Filler/Binder

Sodium Stearyl Fumarate

Lubricant

Titanium Dioxide

Colorant/Opacifier

Ingredient	Purpose	Common Allergen?	Description
Copovidone K25-31	Binder/Film Former	⚠️ Yes — Povidone	A copolymer of vinylpyrrolidone and vinyl acetate used as a binder and film-forming agent in tablets.
Mannitol	Filler/Sweetener	⚠️ Yes — Mannitol	A sugar alcohol used as a sweetener and bulking agent. Can cause osmotic diarrhea in sensitive individuals.
Medium-chain Triglycerides	Solvent/Vehicle	⚠️ Yes — Coconut	Fatty acid esters derived from coconut or palm kernel oil. Used as a solvent and vehicle in oral and topical formulations. May be relevant for individuals with coconut sensitivity.
Polyethylene Glycol 3350	Coating/Osmotic Agent	⚠️ Yes — PEG	A higher-molecular-weight PEG used in tablet coatings and as the active ingredient in osmotic laxatives (MiraLAX). Rare PEG allergies documented.
Ferric Oxide Red	Colorant	No	Red iron oxide pigment used in tablet coatings and capsule shells. A mineral-based colorant, distinct from FD&C synthetic dyes.
Ferric Oxide Yellow	Colorant	No	Yellow iron oxide pigment used in tablet coatings and capsule shells. A mineral-based colorant.
Hamamelis Virginiana Top Water	Skin Conditioner	No	Witch hazel distillate, a plant-derived astringent used in topical formulations to soothe and tone the skin.
Hypromellose	Coating	No	A semisynthetic polymer used for tablet coating. Derived from cellulose.
Low-substituted Hydroxypropyl Cellulose	Disintegrant/Binder	No	A cellulose derivative that swells in water, used as a disintegrant and binder in tablets. Plant-derived.
Microcrystalline Cellulose	Filler/Binder	No	Refined wood pulp used as a filler and binder. Generally inert and well-tolerated.
Sodium Stearyl Fumarate	Lubricant	No	A tablet lubricant used as an alternative to magnesium stearate. Vegetable-derived.
Titanium Dioxide	Colorant/Opacifier	No	A white pigment used for coating opacity. Under regulatory review in some countries.

Exclusion Groups

This medication contains ingredients flagged in the following groups. Patients with these sensitivities should consult their prescriber.

🌾Gluten 🔴Alpha-Gal Syndrome 🥜Peanut / Tree Nut 🎨Dyes & Colorants 🍬Polyols (GI)🌱Not Vegan ☪️Halal Concern ✡️Kosher Concern 🥦Not Vegetarian

AllergenMaps

Ingredient

Purpose

Common Allergen?

Copovidone K25-31

Binder/Film Former

⚠️ Yes — Povidone

Mannitol

Filler/Sweetener

⚠️ Yes — Mannitol

Medium-chain Triglycerides

Solvent/Vehicle

⚠️ Yes — Coconut

Polyethylene Glycol 3350

Coating/Osmotic Agent

⚠️ Yes — PEG

Ferric Oxide Red

Colorant

Ferric Oxide Yellow

Colorant

Hamamelis Virginiana Top Water

Skin Conditioner

Hypromellose

Coating

Low-substituted Hydroxypropyl Cellulose

Disintegrant/Binder

Microcrystalline Cellulose

Filler/Binder

Sodium Stearyl Fumarate

Lubricant

Titanium Dioxide

Colorant/Opacifier