Acetaminophen, Chlorpheniramine maleate, Dextromethorphan hydrobromide, Phenylephrine hydrochloride 250 mg / 10 mg / 5 mg / 2 mg

Generic for CHILDRENS PLUS MULTI SYMPTOM COLD

TABLET, EFFERVESCENTORALBayer HealthCare LLC.NDC: 0280-1560Updated: Mar 2026

Active Ingredients

ASPIRIN — 250 mg

DEXTROMETHORPHAN HYDROBROMIDE — 10 mg

PHENYLEPHRINE HYDROCHLORIDE — 5 mg

CHLORPHENIRAMINE MALEATE — 2 mg

Inactive Ingredients (Fillers)

⚠️ 3 ingredients flagged as common allergens

FD&C Red No. 40

⚠️ Yes — Dye

Colorant

A widely used artificial red dye. Among the most common dye allergens.

Mannitol

⚠️ Yes — Mannitol

Filler/Sweetener

A sugar alcohol used as a sweetener and bulking agent. Can cause osmotic diarrhea in sensitive individuals.

Saccharin Sodium

⚠️ Yes — Saccharin

Sweetener

An artificial sweetener. Rare sensitivities reported, including skin reactions.

Acesulfame Potassium

Sweetener

Anhydrous Citric Acid

pH Adjuster/Buffer

Magnesium Stearate

Lubricant

Maltodextrin

Filler/Binder

Sodium Bicarbonate

Buffer/Effervescent Agent

Ingredient	Purpose	Common Allergen?	Description
FD&C Red No. 40	Colorant	⚠️ Yes — Dye	A widely used artificial red dye. Among the most common dye allergens.
Mannitol	Filler/Sweetener	⚠️ Yes — Mannitol	A sugar alcohol used as a sweetener and bulking agent. Can cause osmotic diarrhea in sensitive individuals.
Saccharin Sodium	Sweetener	⚠️ Yes — Saccharin	An artificial sweetener. Rare sensitivities reported, including skin reactions.
Acesulfame Potassium	Sweetener	No	A non-caloric artificial sweetener (Ace-K) approximately 200 times sweeter than sugar. Used to improve taste in oral medications.
Anhydrous Citric Acid	pH Adjuster/Buffer	No	Water-free citric acid used to adjust pH and enhance drug stability. Typically derived from fermentation of corn sugar.
Magnesium Stearate	Lubricant	No	A lubricant that prevents ingredients from sticking to manufacturing equipment.
Maltodextrin	Filler/Binder	No	A starch-derived carbohydrate used as a filler, binder, and coating agent. Typically derived from corn — may be relevant for corn-sensitive individuals.
Sodium Bicarbonate	Buffer/Effervescent Agent	No	Baking soda. Used as a buffering agent, antacid, or effervescent component in tablets and solutions.

Exclusion Groups

This medication contains ingredients flagged in the following groups. Patients with these sensitivities should consult their prescriber.

🌾Gluten 🔴Alpha-Gal Syndrome 🎨Dyes & Colorants 🍬Polyols (GI)🌱Not Vegan ☪️Halal Concern ✡️Kosher Concern 🥦Not Vegetarian

Dietary & Safety Information

Cross-Contamination Risk (source-dependent)

1 ingredient may have cross-contamination risk with gluten (source-dependent):

Maltodextrin — May contain (source-dependent)

Alpha-Gal Syndrome Risk

1 ingredient may contain mammalian-derived components:

Magnesium Stearate(Possible — Stearates can be plant- or animal-derived (verify source).)

Allergen-Free Alternatives

Other versions of Acetaminophen, Chlorpheniramine maleate, Dextromethorphan hydrobromide, Phenylephrine hydrochloride that avoid allergens found in this formulation.

AmeriSource Bergen